Pradaxa - First New Oral Medication To Stop Blood Clotting In Over 50 Years Launched In Ireland Today Part 2

Pradaxa*  does  not  require  coagulation  monitoring**(7,8),  which  system patients  do  not  need  to  have  correspondent blood testing to watch over coagulation amusement. Â  Pradaxa*  also  does  not  interact  with  food  and  have a dwindling potential  for  interactions  with  drugs  metabolised  by  cytochrome P450 enzymes.(9) Pradaxa*  works  by  target and inhibit thrombin, the crucial and knob enzyme implicated inside the yield of blood clot.(10,11) The  granting  of the licence in support of Pradaxa* via the European Medicines Agency (EMEA)  track lint the submission of efficacy and sanctuary action in February 2007 from  the  phase  III  RE-NOVATE  and RE-MODEL chamber.(12,13) Â  Oral, once each hours of daylight direction of both 150 mg and 220 mg Pradaxa* be demonstrated to be  as  effective  and  well  tolerate in place of injectable enoxaparin (40 mg) in preventing  VTE  and  all  cause  mortality repeated full hip understudy surgery  and  total  knees replacement surgery in the RE-NOVATE and RE- MODEL tribunal, respectively.(12,13) With  all  anticoagulant  agents it be momentous to optimise the be a foil for of efficacy  and  safety. Â  In  addition  to the critically important bleeding profile,  hepatic  and  cardiac  safety  requirements to be considered, furthermore as tolerability.  In both the RE-NOVATE and RE-MODEL trials, the rate and severity  of  major  bleeding  (including  those  occurring at the surgical site), observed beside Pradaxa* was comparable to enoxaparin.

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