Combination Vaccines May Improve Immunization Coverage Rates In Infants, New Study Suggests

The survey evaluate the shot what go formerly of infant born relating January and September 2003, next to ceaseless enrollment within the Georgia Medicaid Program in shop at of at tiniest 24 months later birth, identified from administrative contend of the Georgia Department of Community Health. Infants who be eligible for the study were distributed into two cohort. The muddle crew (N=1990) be made wakeful of those infants who received at least one dose of PEDIARIX [Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed (DTaP), Hepatitis B (Recombinant, HepB) and Inactivated Poliovirus Vaccine (IPV) Combined] and the arm group (N=1990) consisted of those who were immunize with separated injection of DTaP, HepB and IPV or alternate combination (DTaP-Hib or HepB-Hib)]. Each babe-in-arms in the combination vaccine group was matched using sexual characteristics and birth date to an infant in the component vaccine group. Immunization coverage rates were evaluated at 24 months of age by relate the distinction of actual vaccination administered according to the ACIP/AAP/AAFP recommended immunization chart.

Results from the analysis fete that the combination cohort clench by a long way difficult coverage rates than the component cohort for 4 dose of diphtheria, tetanus and pertussis (DTaP) vaccine (58.0 percent vs. 43.5 percent; p<0.001); 3 doses of polio vaccine (71.9 percent vs. 49.6 percent; p<0.001); and 3 doses of hepatitis B vaccine (49.6 percent vs. 22.0 percent; p<0.001). In optional left-over, higher coverage rates were also see for the combination cohort compare to the component cohort for unmistaken vaccines given in the second year of enthusiasm: measles, mumps and rubella vaccine (MMR) (86.1 percent vs. 81.4 percent; p<0.001); varicella vaccine (86.1 percent vs. 81.4 percent; p<0.001); and Haemophilus influenzae air b (Hib) (71.7 percent vs. 55.9 percent; p<0.001). Coverage rates were also higher in the combination cohort compared to the component cohort for the 4:3:1:3:3:1 set combination (includes 4 doses of DTaP, 3 doses of polio, 1 dose of MMR, 3 doses of Hib, 3 doses of hepatitis B, and 1 dose of varicella vaccine (34.3 percent vs. 14.9 percent; p<0.001).

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